The sustained fight against malaria has led to massive strides being made against the disease in the past few decades with malaria almost going extinct in most parts of the world. However, data available for Sub-Saharan Africa still paints a dismal picture, with over 96% of malaria deaths worldwide being reported from the continent alone in 2020, according to the World Health Organization. So, what explains these high numbers and what lies behind the region’s persistent malaria prevalence?