In a recently published article, the World Health Organization recognized the need for the development of novel approaches and continued research to accelerate progress in the fight against malaria. Malaria is a preventable and treatable disease which is spread through the bite of the female Anopheles mosquito. Since this discovery was made by Sir Ronald Ross in 1897, the fight against the disease has increasingly relied on controlling the insect vectors that transmit it. For decades after World War II, indoor residual spraying (IRS) was the only vector-control strategy used to protect people against mosquitoes. It was not until the 2000s that insecticide-treated nets (ITNs) were added to the malaria toolbox. Over the years, these two strategies have been deployed globally and remarkable gains have been made in the fight against malaria between 2000-2015.