The fourth meeting of the Open-Ended Working Group (WG2020-4) on the Post-2020 Global Biodiversity Framework (GBF) took place in Nairobi, Kenya from June 21 to 26. The Framework will define targets and pathways for the conservation and sustainable use of biodiversity over the next decade and beyond, making it a critical tool for the world to stop and reverse the current catastrophic trends in biodiversity loss.