The third webinar of the 2022 Gene Drive Webinar Series provided participants with an overview of the different dimensions of gene drive impact and risk assessments, including environmental and socio-economic aspects. An initiative led by the Outreach Network for Gene Drive Research and the ISAAA SEAsiaCenter, the panel “Integrating Social, Economic and Health Aspects Into the Decision-making Process” delved into gene drive’s potential social, economic and health impacts and how experts are integrating these aspects into risk assessment as research advances.