The fourth and last meeting of the Open-Ended Working Group (WG2020-4) on the Post-2020 Global Diversity Framework (GBF) will take place in Nairobi, Kenya from June 21 to 26. The Post-2020 Framework will define targets and pathways for the conservation and sustainable use of biodiversity over the next decade and beyond. Across regions, challenges to conservation and biodiversity are rapidly mounting. The new Framework is an opportunity to stop and reverse the current catastrophic trends in biodiversity loss.