A new spatial and temporal modeling study captures the evolution of malaria incidence by region from 2000 to 2017 using higher-resolution maps. The findings will help decision-makers to identify with great precision the most critical regions, improving resource allocation, program planning and implementation, and monitoring initiatives. The research focused on malaria cases caused by the Plasmodium falciparum (Pf) parasite, the most virulent type of the disease, which is mainly concentrated in Sub-Saharan Africa.